A Model for the structure of the SOS-regulated UmuD protein

Sutton, M. D.*; Guzzo, A.*; Narumi, Issei; Costanzo, M.*; Altenbach, C.*; Ferentz, A. E.*; Hubbell, W. L.*; Walker, G. C.*

DNA Repair, 1(1), p.77 - 93, 2002/01

UmuD protein is a regulatory subunit of DNA polymerase V. This protein forms a complex with UmuC protein, a catalytic subunit of DNA polymerase V, and plays a important role in error-prone translesion DNA synthesis, which serves as the mechanistic basis for most DNA-damaging agent and UV light mutagenesis. In this paper, based on the results of a combination of experimental studies, we have developed a refined model for the structure of the UmuD homodimer. Implications of the structural change of UmuD protein with respect to its roles in managing the action of DNA polymease V are discussed.